The reference site for Tolazamide

Tolazamide is an oral blood glucose lowering drug used for people with Type 2 diabetes. It is part of the sulfonylurea family (ATC A10BB).

WHAT IS Tolazamide?

Tolazamide belongs to the class of drugs known as sulfonylureas. It works by stimulating the release of your body’s natural insulin, thereby lowering your blood sugar.

Tolazamide is used along with a proper diet and exercise program to control high blood sugar in people with type II diabetes (non-insulin-dependent diabetes).

Effectively controlling high blood sugar helps prevent heart disease, strokes, kidney disease, blindness, and circulation problems, as well as sexual function problems (impotence).

 

Brand Name(s): Tolinase
CAS nº: 1156-19-0
(tole AZ a mide)

 

Product Info

The sections below will provide you with more specific information and guidelines related to tolazamide and its correct use. Please read them carefully.

FDA Information

Tolazamide was approved by the Food and Drug Administration on October 28th, 1999. A prescription is required for this medicine.

Please visit the official site of the FDA for further information.

Why is this medication prescribed?

Tolazamide is used along with a proper diet and exercise program to control high blood sugar in people with type II diabetes (non-insulin-dependent diabetes).

Effectively controlling high blood sugar helps prevent heart disease, strokes, kidney disease, blindness, and circulation problems, as well as sexual function problems (impotence).

Tolazamide belongs to the class of drugs known as sulfonylureas. It works by stimulating the release of your body’s natural insulin, thereby lowering your blood sugar.

Other uses for this medicine

This medication has not been approved for any alternative uses other than those mentioned in the product information section.

Dosage and using this medicine

Tolazamide comes in tablets to be taken orally.

Take tolazamide exactly as directed by your doctor. If you do not understand these instructions, ask your pharmacist, nurse, or doctor to explain them to you.

Take each dose with a full glass (8 ounces) of water.

Tolazamide is usually taken before breakfast or the first main meal if it is taken once a day, or before meals if it is taken multiple times each day. Follow your doctor’s instructions.

Your healthcare provider may recommend regular monitoring of blood sugar levels with blood or urine tests.

Furthermore, it is important to take tolazamide regularly to get the most benefit. Please do not change your dose of tolazamide without first talking to your doctor.

What special precautions should I follow?

BEFORE TAKING TOLAZAMIDE:

Tell your doctor if you have kidney disease, have liver disease, have thyroid disease, have type 1 diabetes, have a serious infection, illness, or injury or need surgery. You may not be able to take tolazamide, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above.

Many medicines may increase or decrease the effects of tolazamide or affect your condition. Before taking tolazamide, please inform your doctor if you are taking any of the following medicines: aspirin or another salicylate such as magnesium/choline salicylate (Trilisate®), salsalate (Disalcid®, others), choline salicylate (Arthropan®), magnesium salicylate (Magan®), or bismuth subsalicylate (Pepto-Bismol®); a nonsteroidal anti-inflammatory drug (NSAID) such as ibuprofen (Motrin®, Advil®, Nuprin®, others), ketoprofen (Orudis®, Orudis KT®, Oruvail®), diclofenac (Voltaren®, Cataflam®), etodolac (Lodine®), indomethacin (Indocin®), nabumetone (Relafen®), oxaprozin (Daypro®), naproxen (Anaprox®, Naprosyn®, Aleve®), and others; a sulfa-based drug such as sulfamethoxazole-trimethoprim (Bactrim®, Septra®), sulfisoxazole (Gantrisin®), or sulfasalazine (Azulfidine®); a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan®), tranylcypromine (Parnate®), or phenelzine (Nardil®); a beta-blocker such as propranolol (Inderal®), atenolol (Tenormin®), acebutolol (Sectral®), metoprolol (Lopressor®), and others; a diuretic (water pill) such as hydrochlorothiazide (HCTZ®, Hydrodiuril®), chlorothiazide (Diuril®), and others; a steroid medicine such as prednisone (Deltasone®, Orasone®, others), methylprednisolone (Medrol®, others), prednisolone (Prelone®, Pediapred®, others), and others; a phenothiazine such as chlorpromazine (Thorazine®), fluphenazine (Prolixin®, Permitil®), prochlorperazine (Compazine®), promethazine (Phenergan®), and others; phenytoin (Dilantin®); isoniazid (Nydrazid®); or prescription, over-the-counter, or herbal cough, cold, allergy, or weight loss medications. You may require a dosage adjustment or special monitoring if you are taking any of the medicines listed above.

Tell your doctor and dentist that you are taking this medication before you undergo any surgery.

Patients 65 years of age and older may have a stronger reaction to tolazamide and may require a reduced dose.

Tolazamide is in the FDA pregnancy category C. This means that it is not known whether tolazamide will be harmful to an unborn baby. Do not take this medication without first talking to your doctor if you are pregnant or could become pregnant during treatment. Insulin is usually the drug of choice for controlling diabetes during pregnancy.

Additionally, it is not known whether tolazamide passes into breast milk. Do not take tolazamide without first talking to your doctor if you are breast-feeding a baby.

It is also important that you follow your diet, medication, and exercise routines closely. Changing any of them can affect blood sugar levels.

Avoid alcohol intake as it lowers blood sugar and may interfere with your diabetes treatment.

What should I do if I forget a dose?

Take the missed dose as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and take only the next regularly scheduled dose.

It is strongly advised never to take a double dose of this medication.

What side effects can this medication cause?

Stop taking tolazamide and seek emergency medical attention if you experience an allergic reaction (such as difficulty breathing, closing of the throat, swelling of the lips, tongue, or face, or hives).

Other, less serious side effects from tolazamide result mostly from blood sugar levels that are either too high or too low. You should be familiar with the symptoms of both high and low blood sugar levels and know how to treat both conditions. Also, be sure your family and close friends know how to help you in an emergency situation.

Low blood sugar may occur when too much tolazamide is taken, when meals are missed or delayed, if you exercise more than usual, during illness, especially with vomiting or diarrhea, if you take other medications, after drinking alcohol, or in other situations.

Hypoglycemia or low blood sugar has the following symptoms:

shaking
headache
cold sweats
pale, cool skin
anxiety
difficulty concentrating

Keep hard, sugary candy, chocolate, fruit juice, or glucose tablets on hand to treat episodes of low blood sugar.

On the other hand, increased blood sugar may occur when not enough tolazamide is taken, if you eat significantly more food than usual, if you exercise less than usual, if you take other medications, during fever or other illness, and in other situations.

Hyperglycemia or high blood sugar has the following symptoms:

increased thirst
increased hunger
increased urination

There may be an increased risk of death due to cardiovascular (heart and blood vessels) complications with the use of tolazamide when compared to the treatment of diabetes with diet or diet plus insulin. The long-term use of tolazamide should be discussed with your doctor.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What storage conditions are needed for this medicine?

Always keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

Please remember to throw away any medication that is outdated or no longer needed. If you have any questions, talk to your pharmacist about the proper disposal of your medication.

In case of an emergency/overdose

In the case of a suspected overdose, call your local poison control center on 1-800-222-1222. However, if the victim has collapsed or is not breathing, then call the local emergency services immediately on 911.

Symptoms of overdose may include:

hunger
nausea
anxiety
cold sweats
weakness
drowsiness
unconsciousness
coma

Product Images

PICTURES OF TOLAZAMIDE PILLS

Below you will find images and specific information on the principal types of tolazamide that exist, including their respective brand name(s), strength, inscription codes, manufacturers and/or distributors.

The information below includes general information and guidelines for patients taking this medication and should never be used to substitute professional medical advice that can be provided by a qualified physician or family doctor.

Name: TOLAZAMIDE
Strength(s): 250 MG
Imprint: Z 2979
Manufacturer: IVAX PHARMACEUTICALS
Distributor: RUGBY LABS.

Name: TOLAZAMIDE
Strength(s): 250 MG
Imprint: MYLAN 217 | 250
Manufacturer: MYLAN

Name: TOLAZAMIDE
Strength(s): 500 MG
Imprint: MYLAN 551
Manufacturer: MYLAN

Name: TOLAZAMIDE
Strength(s): 500 MG
Imprint: Z 2980
Manufacturer: IVAX PHARMACEUTICALS

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